PATH370 Pathophysiology

Week 1 Discussion

Complete your Week 1 required discussion prompts.

Discussion Prompt #1

Review the following case study and discuss the question that follows.

TL is a 62-year-old male who was in a car wreck and who has been hospitalized for compartment syndrome from a left leg crush injury. He has areas of necrosis (tissue ischemia) seen along his calf. Tissue necrosis is areas of dead cells. It is imperative that the necrosis does not increase.

1. Discuss the etiologies of cellular injury and death and what can be done for TL to maximize his care.

Discussion Prompt #2

Identify diseases with idiopathic, iatrogenic, and multifactorial causes, and discuss the importance of identifying risk factors for diseases. Explain how measurements of structural, physiologic, biochemical, and genetic parameters provide a basis for disease screening and identification of risk factors.

Please note: There is an automatic 10% deduction of points for late postings.


PATH370 Pathophysiology

Week 2 Discussion

Complete your Week 2 required discussion prompts.

Discussion Prompt #1

Review the following case study and discuss the questions that follow.

EO is an 8-year-old girl with a history of asthma and allergy to bee stings. She has been brought to the clinic complaining of a throat infection. Her health care provider prescribes a course of penicillin to manage her current infection and cautions her parents to watch her closely for a reaction.

What type of reaction is the health care provider concerned about, and why?

Explain the role of IgE and mast cells in type I hypersensitivity reactions. Why might EO react adversely to the antibiotic with the first use?

What would you tell EO’s parents to look for when they are assessing for a reaction?

Discussion Prompt #2

Watch The Human Immune System: When It Turns Against the Body video series below. Given the complexities of treatment associated with HIV/AIDS, what elements do you think are important in an effective care plan for those with HIV/AIDS? Also, discuss the importance of balancing the risks and benefits of treatment options. What is the clinician’s role in assisting the family/patient with making treatment decisions? Lastly, identify and discuss one new thing that you learned about this disease.


The Human Immune System: When It Turns Against the Body Series

1. Autoimmune disease overview7:17

2. HIV/AIDS overview3:24

If you are using the Firefox browser and experiencing difficulty loading any of these videos, update your Flash player using this link You may also change your browser to Chrome to view.

Please note: There is an automatic 10% deduction of points for late postings.


PATH370 Pathophysiology

Week 3 Discussion

Complete your Week 3 required discussion prompts.

Discussion Prompt #1

How does an understanding of the mechanisms of the heart help you in treatment of your patient regardless of the illness? How does basic cardiac monitoring factor into caring for your patient? How do you care for patients with dysrhythmia? Share some of your best practices.

Discussion Prompt #2

Review the following case study and discuss the questions that follow.

CC is a previously healthy 27-year-old man admitted to the critical care unit after an accident in which he was hit by a car and dragged along the pavement for nearly 100 feet. He suffered a frontal contusion, fractured clavicle and ribs, and extensive abrasions on his arms, legs, side, back, and buttocks. On admission, he was tachycardic, hypotensive, unresponsive, and ventilating poorly. He was placed on a mechanical ventilator and given IV fluids for the treatment of his shock. CC responded well to fluids, with an increase in blood pressure and an improvement in urine output.

Based on his case history and responsiveness to fluid therapy, what type of shock was CC experiencing?

What other clinical findings would be helpful in confirming the type of shock? Why?

Because of his many open wounds and invasive lines, CC is at risk for sepsis and septic shock. What clinical findings would suggest that this complication has developed?

What is the link between sepsis and multiple organ dysfunction syndrome (MODS)?

Please note: There is an automatic 10% deduction of points for late postings.






PATH370 Pathophysiology

Week 4 Discussion

Complete your Week 4 required discussion prompts.

Discussion Prompt #1

In this week’s material on lung function, two diseases tend to emerge as clinically important: COPD and lung cancer. Please go onto the CDC website ( to look up facts and figures on one of these two diseases. What is its burden on society? How can you, working on the front lines of disease management, help to relieve the burden of the disease on society?

Discussion Prompt #2

Read the case study below. Answer and discuss the questions that follow.

ND is a 82-year-old female who lives in a skilled nursing facility. She suffers from rheumatoid arthritis, coronary artery disease, chronic bronchitis, and hypertension. She is wheelchair bound and tends to spend most of her days in bed. She smoked for 52 years but quit 14 years ago. She has lost 10 pounds in the last month and has had a productive cough for about 2 weeks that has copious amounts of white to yellow mucous. Over the last 3 days, she has refused to get out of bed and has been refusing to eat or drink. This morning she is confused, has a fever, and is coughing continuously. Her sputum now is rust-colored. Her lungs sounds are coarse rhonchi throughout with crackles and diminished lung sounds in her right middle lobe area. Her vital signs are BP 86/54, HR 98, RR 28, and temperature 102.4. She is being admitted to the hospital.

Pneumonia can be classified many different ways. Which classification of pneumonia best fits ND’s situation? Explain. What is the most probable cause of ND’s pneumonia? Which diagnostic tests would you expect to be done to diagnose ND’s pneumonia?

Please note: There is an automatic 10% deduction of points for late postings.


PATH370 Pathophysiology

Week 5 Discussion

Complete your Week 5 required discussion prompts.

Discussion Prompt #1

ESRD (end-stage renal disease) is the last stop in pathology for the kidney, and it is not a place we want a patient to be. However, there are many ways to intervene before a patient gets to this stage. Please visit the National Kidney Foundation website ( and pick one best practice you can share with your patients to promote kidney health. Please share that practice with the class, and why you chose it.

Discussion Prompt #2

Review the following case study and complete the questions that follow.

JH is a 12-year-old boy diagnosed several months ago with nephrosis following postinfectious glomerulonephritis secondary to an episode of pneumococcal pneumonia. He has been coming to the clinic to have his condition monitored and therapies adjusted as needed. At his latest clinic visit, a decrease in urine output, increasing lethargy, hyperventilation, and generalized edema are noted. Trace amounts of protein are detected in JH’s urine by dipstick. Blood is drawn for laboratory analysis, and the results are as follows:? pH = 7.36 ?PaCO2 = 33 mm Hg ?PaO2 = 100 mm Hg ?HCO3 – = 18 mEq/L ?Hct = 30% ?Na+ = 130 mEq/L ?K+ = 5.4 mEq/L ?BUN = 58 mg/dl ?creatinine = 3.9 mg/dl ?albumin = 2.0 g/dl

How would a pneumococcal infection lead to glomerulonephritis? How can glomerulonephritis result in nephrosis?

Use JH’s laboratory values to determine if he is still experiencing nephrosis or if his condition is progressing to renal failure.

What additional physical or laboratory findings would be helpful in determining JH’s degree of renal impairment?

How will JH’s therapy change if his condition has progressed from nephrosis to uremia?

Please note: There is an automatic 10% deduction of points for late postings.


PATH370 Pathophysiology

Week 6 Discussion

Complete your Week 6 required discussion prompts.

Discussion Prompt #1


Click to view the presentation.

Complete the diagnostic exercise above. After you have viewed each person, select one of the individuals, and based on his or her health assessment, develop a health plan to help them prevent the disease and improve their quality of life. Your plan should include health care recommendations, educational materials, support systems for making lifestyle changes, and tools and resources for managing and monitoring symptoms.

As part of your plan, include the following:

Provide a brief summary of the individual’s health assessment, the physiologic signs and symptoms of the individual’s highest disease risk, and the impact of that disease on his/her functional health status.

Provide a health plan for risk prevention addressing diet, exercise, health monitoring recommendations, pharmacological aids, diagnostic testing recommendations, and additional lifestyle changes. Clearly explain the interrelationships between pathophysiology, pharmacology, diagnostic testing, and management on the individual’s health and the disease.

Identify and summarize at least one current pharmacological advancement or a key piece of substantiated research in the treatment or prevention of the disease. Cite your source(s).

Identify two or more websites to aid in the physical and mental well-being of the individual. Include the web links and a summary of the features and benefits of each site in a brief paragraph. Explain how specific components/features of the site can benefit your individual’s health care.

Discussion Prompt #2

What are the components of a successful diabetes care team? Is this something that is practiced where you currently work? Of the best practices shared in the video clips below, which do you think is most important? How would you incorporate this into your practice?

Diabetes in Clinical Practice

1. Components of a diabetes team4:13

2. Overview of the diabetes team3:49

3. Screening test1:17

4. Assisting patients with self management1:35

5. Foot inspection0:49

6. Glycemic emergencies2:01.